Of 22 patients, 5 had persistent symptoms, and signs of chronic heart failure.

that Coxsackie B virus infection may result in permanent heart damage. Myocarditis can damage the heart muscle causing it to become thick and swollen. Coxsackie viruses are enteroviruses; there are numerous serotypes. The aim of the present study was to assess the potential role of CV-B in the etiology of infectious heart disease in hospitalized patients.
The diseases can cause symptoms ranging from mild gastrointestinal upsets (illness relating to the stomach or intestines) to paralysis, heart damage and birth defects, although the subclinical and mild infections are the most common.

Such viral infections manifest in the form of myocarditis, pericarditis, hepatitis, pleurodynia, etc. Tissue culture and murine experimental models were employed to study the mechanism by which Coxsackie B virus might cause severe focal necrosis of human cardiac tissue.
Hastreiter and Miller (I964) stressed that myocarditis and endocardial fibroelastosis may bestages ofthe samedisease, often coexisting clini-cally and histologically.

Coxsackie myocarditis is inflammation and weakness of the heart muscle caused by a viral infection (Coxsackie virus) that reaches the heart. In 19 patients a virus aetiology of the heart disease was proved by isolation of one of the subtypes of Coxsackie B virus and/or on the basis of fourfold rise in neutralizing antibody titre in paired sera.

Symptomology and Outcome: Coxsackie B infection is characterized by fever, fatigue, malaise and chest pains. Infection with the Coxsackie B virus is … The Type A Coxsackie virus commonly causes the hand, foot and mouth disease and the Type B group usually causes more serious conditions.

In the diagnostic approach, the positive results were confirmed using a variety of techniques. Coxsackieviruses B (CV-B) are known as the most common viral cause of human heart infections. The coxsackie B viruses, like most enteroviruses are transmitted fecal-orally and through direct contact with mucosal secretions.

There are numerous disease conditions that can be caused by coxsackie viruses and they are listed below. Infection of the heart by a coxsackie B virus … Virus studies as well as other routine tests were carried out on all patients.

Group A virus also causes herpangina, blisters on the tonsils and soft palate, which presents as a sore throat. The muscles are locally tender.

Usually caused by Coxsackievirus B.

Pain on inspiration is similar to pleuritic pain and pulmonary embolism may be suspected.

In 19 patients a virus aetiology of the heart disease was proved by isolation of one of the subtypes of Coxsackie B virus and/or on the basis of fourfold rise in neutralizing antibody titre in paired sera. Virus studies as well as other routine tests were carried out on all patients.

Similarly, RT-PCR as well as immunohistochemistry revealed an association between enterovirus infection, in particular the cardiotropic coxsackie B enterovirus, serotypes B1-B5 and myocarditis .

J Clin Pathol 22:654–658 PubMed Google Scholar Lutton CW, Gauntt CJ (1986) Coxsackievirus B3 infection alters plasma membrane of neonatal skin fibroblasts.


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