De Azambuja E, Cardoso F, de Castro G Jr, et al: Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients. 96:1504–1513. Patients. Immunohistochemical assessment of Ki67 labeling index (IHC Ki67) has been described as a prognostic and predictive marker for breast cancer. Studies have partly demonstrated the clinical validity of Ki-67 as a predictive marker in the neoadjuvant setting, but the question of the best cut-off points as well as the importance of this marker as a prognostic factor in partial responder/non-responder groups remains uncertain. Ki67 in breast cancer: prognostic and predictive potential Rinat Yerushalmi, Ryan Woods, Peter M Ravdin, Malcolm M Hayes, Karen A Gelmon The leading parameters that defi ne treatment recommendations in early breast cancer are oestrogen-receptor, progesterone-receptor, and human epidermal growth-factor status. 7. Ki67 in breast cancer: prognostic and predictive potential. Yerushalmi R, Woods R, Ravdin PM, Hayes MM and Gelmon KA: Ki67 in breast cancer: prognostic and predictive potential. Br J Cancer. Background: Ki-67 is a widely used marker of tumor proliferation, but the prognostic value of ki-67 in triple-negative breast cancer (TNBC) has not been comprehensively reviewed.

Several clinical trials have investigated the prognostic and predictive usefulness of molecular markers. Recommend Documents. 2007.PubMed/NCBI. 297KB Sizes 0 Downloads 0 Views. Ki67 has been identified as a prognostic and predictive marker in ER-positive breast cancer.
A key tool for monitoring breast cancer patients under neoadjuvant treatment is the identification of reliable predictive markers. The Ki-67 index was measured in 3,652 cases with primary breast cancer from 1987 to 2009 in Kumamoto City Hospital, Japan. Because cancer cells grow and divide rapidly, Ki-67 is sometimes considered a good marker of proliferation (tumor marker), helping your doctor follow the progress of cancer. We conclude that the automated global Ki67 scoring is feasible and shows clinical validity, which, however, needs to be confirmed in a larger cohort before clinical implementation. 2020 Jun 22. doi: 10.1007/s10549-020-05752-w. Online ahead of print. 7. The potential value of Ki67 as a prognostic biomarker for breast cancer emerges strongly from published studies, notwithstanding variations in study design and methodology. 96:1504–1513. Br J Cancer. The aim of this study was to compare the prognostic potential for Ki67 hot spot scoring and global scoring using different digital image analysis (DIA) platforms. 2007.PubMed/NCBI. As Ki 67 is one of the proliferation genes assessed routinely by IHC in different malignancies, several investigators have studied its prognostic and predictive value in different stages of breast cancer treatment. 1 According to the recent St. Gallen consensus conference, the Ki67 … 3 Ki67 LI has also been considered as a promising biomarker to select patients who could benefit from chemotherapy. Prognostic Potential of Automated Ki67 Evaluation in Breast Cancer: Different Hot Spot Definitions Versus True Global Score Breast Cancer Res Treat. The use of Ki67 as a predictive and prognostic marker in breast cancer has been widely investigated.

With limited predictive value, molecular markers have mainly been used to identify prognostic subgroups in which the indication for chemotherapy is doubtful and the prognosis is favorable enough for chemotherapy to be avoided. However, its use in breast cancer is controversial. Similar to the issues of quality testing with other prognostic or predictive markers, such as HER2 or ER, the reported studies of Ki67 use various methods for assessing and scoring Ki67, which makes comparisons difficult. Prognostic and Predictive Factors in Breast Cancer Kyle T. Bradley, MD, MS CAP Cancer Committee Breast cancer is the most common malignant tumor in American women and is second only to lung cancer as a cause of cancer-related mortality.1 During the past two decades the mortality rate has declined significantly, primarily due to the early use of adjuvant systemic therapy as well as detection … Report. Review Ki67 in breast cancer: prognostic and predictive potential Rinat Yerushalmi, Ryan Woods, Peter M Ravdin, Malcolm M Hayes, Karen A Gelmon Lance... Download PDF . The proliferation-associated biomarker Ki67 has potential utility in breast cancer, including aiding decisions based on prognosis, but has unacceptable inter- and intralaboratory variability. De Azambuja E, Cardoso F, de Castro G Jr, et al: Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.


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